Responder Analysis: Loser x 4

If outcome is a mix of a change in score and a dichotomization (responder), i.e. having a certain
amount of change and reaching a given score threshold, all assumptions as described in BBR ch.14 would still apply. For example, what if distribution of baseline score is bimodal or multimodal? Different disease processes, measurement errors, or differential ceiling/floor effect would probably unmdermine the outcome.

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